THESIS ON MACROCYTIC ANEMIA

Patients above the age of 15 years with macrocytic anemia. Patients with decompensated liver disease, chronic kidney disease, Hemolytic anemia, Hemorrhagic disease. Megaloblastic anemia due to Vitamin B 12 or folate deficiency remains the most important cause of macrocytic anemia. Abstract Purpose of study This study was conducted to study the clinical and laboratory parameters in patients with macrocytic anemia and to determine the etiology of macrocytic anemia with special reference to megaloblastic anemia. Indian J Hematol Blood Transfus. To identify the etiology of macrocytic anemia in patients presenting to tertiary care hospital in South India PSG Hospitals.

Post splenectomy and pregnant patients. To evaluate the causes for megaloblastic anemia. Even though many diseases might lead to macrocytic anemia our study shows megaloblastic macrocytosis as the most common cause. Macrocytosis of the erythrocytes: Upper GI endoscopy with deep duodenal biopsy should be done in all patients with megaloblastic anaemia. Author information Article notes Copyright and License information Disclaimer.

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Etiological Profile of Macrocytic Anemia in Patients Admitted in PSG Hospitals

This study was conducted to study the clinical and laboratory parameters in patients with macrocytic anemia and to determine the etiology of macrocytic anemia with special reference to megaloblastic anemia.

We observed in our study that being a non vegetarian does not protect against Vitamin B12 deficiency. Tarun Kumar Dutta, Email: Support Center Support Center. Am J Med Sc.

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thesis on macrocytic anemia

Vitamin B 12 deficiency and early rise in MCV. Macro-ovalocytes and hyper-segmented neutrophils occurring in peripheral blood smear would significantly favour towards diagnosing megaloblastic anemia. Often we see macrocytosis preceding anemia4,5,6, which is usually not investigated, particularly when anemia is very mild.

Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblastic anemia

Considering megaloblastic anaemia as one of the differentials in pancytopenia is important. Macrocytic anemia is generally classified as megaloblastic or non-megaloblastic anemia. Macrocytic anemia, Non-megaloblastic macrocytic anemia, Bone marrow disorders, Megaloblastic anemia, Myelodysplastic syndrome.

thesis on macrocytic anemia

The mean age of male and female were Megaloblastic anaemia in vegetarian Asians. When there is no response to iron supplementation after a latent period then only the diagnosis of megaloblastic anemia is offered. Status of laboratory testing in the diagnosis of megaloblastic anemia.

A significant proportion of non-vegetarians This article has been cited by other articles in PMC. The clinical significance of macrocytosis. Suspicion at high level, properly eliciting the history and thorough examination of the patient will lead us in diagnosing macrocytic anemia. Heterogeneous group of disorders acting via various known and unkwown processes can lead to macrocytic anemia.

Please review our privacy policy. A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. The prevalence of tropical sprue is also quite great. Bleeding was not a presenting complaint in patients with thrombocytopenia due to B12 deficiency.

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Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblastic anemia

In settings with limited laboratory facilities, a therapeutic trial of vitamins B 12 or folic acid is useful in determining the specific vitamin deficiency. Macrocytosis would be seen even in the absence of anemia. The megaloblastic anemias observed were due to either vitamin B 12 deficiency Result The most common cause of macrocytic anemia was megaloblastic anemia Received Jun 3; Accepted Sep An increased value of MCV, among various other findings at regular laboratory investigations, might be the early feature of various disease states like low vitamin B12 or low folate levels, pre leukemia, drug induced or alcoholism7.

Anemia with a hemoglobin of; a. ABC of clinical hematology: Interpretation of electronically determined macrocytosis.

thesis on macrocytic anemia

The severity of anemia did not have any correlation with the levels of serum B12 or the degree of macrocytosis. Even though many diseases might lead to macrocytic anemia our study shows megaloblastic macrocytosis as the most common cause.