THESIS ON GASTRORETENTIVE DRUG DELIVERY SYSTEM

Floating drug delivery system- A review. Review from previous studies: An updated review on: The stomach primarily aims at processing and transporting food. Either round or spherical shaped dosage form exhibit better property related to other shapes. International Journal of Pharmaceutical Investigation ; 1: How to cite this article:

Minimised factor of risk in resistance in antibiotics owing to stabilised therapeutic levels over prolonged periods removing fluctuations. Slow content release to act as reservoir. Floating drug delivery systems: However now the gas generating matrix is one layer and rest two are drug layers Problematic with solubility in gastric fluid Causing G. Review on gastro retentive drug delivery system. High Density Systems 31, 32 These systems possess density greater than the gastric fluids due to which the system sinks to the bottom and remains in the stomach.

Males have greater GRT than females Age: But, along with the appropriate level of floating force Fminimum levels of gastric contents are needed to permit achievement of buoyancy retention principle and also to keep dosage form buoyant over meal surface. Intragastric floating gastrointestinal drug system.

Gas Generating Systems These systems are further classified as below: Gastric retention time is less during fasting condition due to rise in gastric motility Nature of Meal: However now the gas generating matrix is one layer and rest two are drug layers The following methods have been devised to improve period of retainment of oral dosage form in the stomach viz.

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Multiple units are desirable due to foretell release profile. Recent approaches to increase the gastric residence time of drug delivery systems include bioadhesive systems, floating systems low density systemsnon-floating systems high density systemsmagnetic systems, swelling systems, unfoldable and expandable systems, raft forming systems and superporous systems, biodegradable hydrogel systems.

thesis on gastroretentive drug delivery system

In the literature an apparatus has been described that measures the kinetics of floating force. African Journal of Basic and Applied Sciences ; 3: Review from previous studies: The author reports no declaration of interest.

Erythromycin Drugs that are used for selective release in the colon. Development, optimization and in vitro—in vivo evaluation in healthy human volunteers. Drugs having low solubility at high pH values. These systems are further classified as below: Formulation and evaluation of floating matrix tablet of stavudine. Intragastric floating gastrointestinal drug system. The Non- effervescent floating dosage forms have swellable cellulose type of hydrocolloids, polysaccharides, and matrix-forming polymers like polycarbonate, polyacrylate, polymeth-acrylate, and polystyrene Floating microspheres of valacyclovir HCl: Drugs with narrow absorption window inGastrointestinal tract GIT.

Gas Generating Systems These systems are further classified as below: Gastroretentive drug delivery system. Hydrogel based swelling system takes longer time to swell.

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The floating drug delivery system is a novel approach for the same. Controlled Release Compositions Comprising Nimesulide.

thesis on gastroretentive drug delivery system

They are created in a manner that upon contact with gastric contents CO deilvery is released finally entrapping in swollen hydrocolloids, that makes dosage forms buoyant However the two states are varied upon pattern of motility. A high protein and fat rich diet can increase GRT by 4 to 10h. An unaccustomed drug delivery system of gastroretentive dosage form has evolved.

Recent approaches to increase the gastric residence time of drug gastrodetentive systems include bioadhesive systems, floating systems low density systemsnon-floating systems high density systemsmagnetic systems, swelling systems, unfoldable and expandable systems, raft forming systems and superporous systems, biodegradable hydrogel systems. Its creation has a simplistic approach i.

thesis on gastroretentive drug delivery system

Floating drug delivery for prolonging gastric retention of dosage form. As the system provides with controlled rates of fluctuation, a wider array is provided for selectivity in receptor activation. This system comprises of dual chambers having an impermeable, pressure responsive, movable bladder separation.